发布时间：2023-03-31   浏览次数:10

序号 本校作者 （红色字体为本校通讯作者）              题名 WOS学科 期刊 2021年影响因子 卷 期 页数/DOI 1 Hu,Jianmin;Dai,Bingfa Early detection of visual impairment in young children using a smartphone-based deep learning system Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental NATURE MEDICINE 87.241 / / 10.1038/s41591-022-02180-9 2 Chen,C.;Zheng,B. Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: a prospective multicenter randomized clinical trial Oncology ANNALS OF ONCOLOGY 51.769 34 2 163-172 3 Chen,Chun Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial Biochemistry & Molecular Biology; Cell Biology SIGNAL TRANSDUCTION AND TARGETED THERAPY 38.104 8 1 10.1038/s41392-022-01286-3 4 Yang,Wei-Zhu;Fang,Zhu-Ting Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001) Biochemistry & Molecular Biology; Cell Biology SIGNAL TRANSDUCTION AND TARGETED THERAPY 38.104 8 1 10.1038/s41392-022-01235-0 5 Wang,Zihua A Totipotent All-In-One Peptide Sequentially Blocks Immune Checkpoint and Reverses the Immunosuppressive Tumor Microenvironment ADVANCED MATERIALS   English Article      combination therapy; immune checkpoints; peptide self-assembly; screening P53; CELLS; RESISTANCE; INHIBITORS; INCREASES Immune checkpoint blockade combined with reversal of the immunosuppressive tumor microenvironment (TME) can dramatically enhance anti-tumor immunity, which can be achieved by using multiple-agent therapy. However, the optimal dose and order of administration of different agents remain elusive. To address this dilemma, multiple agents are often grafted together to construct all-in-one totipotent drugs, but this usually comes at the cost of a lack of synergy between the agents. Herein, by comprehensively analyzing the conserved sites of the immune checkpoint and TME drug targets, peptide secondary structures, assembly properties, and other physicochemical properties, a high-content peptide library is designed. By using the 3D-molecular-evolution screening strategy, an efficient and totipotent all-in-one peptide (TAP) is obtained, which possesses the abilities of self-assembling, blocking the PD-1/PD-L1 axis, inhibiting Rbm38-eIF4E complex formation, and activating p53. It is shown that in mice treated with TAP, with either subcutaneous tumors or patient-derived xenografts, PD-L1 is blocked, with increased activation of both T and NK cells whilst reversing the immunosuppressive TME. Moreover, TAP can mitigate tumor activity and suppress tumor growth, showing superior therapeutic effect over antibody-based drugs. [Zhang, Limin; Jiang, Zhenqi; Yang, Xi; Wang, Minxuan; Wu, Shang; Tang, Xiaoying; Wang, Weizhi] Beijing Inst Technol, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Key Lab Cluster Sci,Minist Educ,Minist Ind & Infor, Beijing 100081, Peoples R China; [Jiang, Zhenqi] Beijing Inst Technol, Sch Med Technol, Beijing 100081, Peoples R China; [Yang, Xi] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 201203, Peoples R China; [Qian, Yixia; Jia, Fei; Hu, Zhiyuan; Zhao, Minzhi] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Wang, Zihua] Fujian Med Univ, Ctr Neurosci Res, Sch Basic Med Sci, Fuzhou 350108, Fujian, Peoples R China; [Li, Gang] Shanxi Hosp Tradit Chinese Med, Gastrointestinal Surg, Taiyuan 030012, Peoples R China; [Shang, Hanbing] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Surg, Shanghai 200025, Peoples R China; [Chen, Xiaoyuan] Natl Univ Singapore, Yong Loo Lin Sch Med, Engn, Singapore 119074, Singapore; [Chen, Xiaoyuan] Natl Univ Singapore, Fac Engn, Singapore 119074, Singapore; [Chen, Xiaoyuan] Natl Univ Singapore, Clin Imaging Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore 117599, Singapore Beijing Institute of Technology; Beijing Institute of Technology; Shanghai University of Traditional Chinese Medicine; Chinese Academy of Sciences; National Center for Nanoscience & Technology - China; Fujian Medical University; Shanghai Jiao Tong University; National University of Singapore; National University of Singapore; National University of Singapore Zhang, LM (通讯作者)，Beijing Inst Technol, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Key Lab Cluster Sci,Minist Educ,Minist Ind & Infor, Beijing 100081, Peoples R China. 7520200073@bit.edu.cn; huzy@nanoctr.cn; zhaomz@nanoctr.cn; chen.shawn@nus.edu.sg; wangwz@bit.edu.cn  Jiang, Zhenqi/0000-0002-2685-1327; Zhang, Limin/0000-0002-0176-1798 National Natural Science Foundation of China [22074006, 32101153]; Beijing Natural Science Foundation [2222029]; National University of Singapore [NUHSRO/2020/133/Startup/08]; NUS School of Medicine Nanomedicine Translational Research Programme [NUHSRO/2021/034/TRP/09/Nanomedicine]; NUS School of Medicine Kickstart Initiative [NUHSRO/2021/044/Kickstart/09/LOA]; National Medical Research Council (NMRC) Centre Grant Programme [CG21APR1005]; Youth Science and Technology Research Fund of Basic research projects in Shanxi [201801D221387]; Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]; CAS Project for Young Scientists in Basic Research [YSBR-036] National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC)); Beijing Natural Science Foundation(Beijing Natural Science Foundation); National University of Singapore(National University of Singapore); NUS School of Medicine Nanomedicine Translational Research Programme; NUS School of Medicine Kickstart Initiative; National Medical Research Council (NMRC) Centre Grant Programme; Youth Science and Technology Research Fund of Basic research projects in Shanxi; Strategic Priority Research Program of Chinese Academy of Sciences(Chinese Academy of Sciences); CAS Project for Young Scientists in Basic Research The authors are grateful for financial support from National Natural Science Foundation of China (22074006, 32101153), Beijing Natural Science Foundation (2222029), The National University of Singapore Start-up Grant (NUHSRO/2020/133/Startup/08), NUS School of Medicine Nanomedicine Translational Research Programme (NUHSRO/2021/034/TRP/09/Nanomedicine), NUS School of Medicine Kickstart Initiative (NUHSRO/2021/044/Kickstart/09/LOA), National Medical Research Council (NMRC) Centre Grant Programme (CG21APR1005), The Youth Science and Technology Research Fund of Basic research projects in Shanxi (201801D221387), Strategic Priority Research Program of Chinese Academy of Sciences (XDB36000000), and CAS Project for Young Scientists in Basic Research (YSBR-036). The authors thank Analysis and Testing Center in Beijing Institute of Technology on the experimental data acquisition.  68 0 0 34 34 WILEY-V C H VERLAG GMBH WEINHEIM POSTFACH 101161, 69451 WEINHEIM, GERMANY 0935-9648 1521-4095  ADV MATER Adv. 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Endocrinology & Metabolism CARDIOVASCULAR DIABETOLOGY 8.949 22 1 10.1186/s12933-023-01737-3 47 Chen,Xinwang;Chen,Xiangqi Exposure to phthalate increases the risk of eczema in children: Findings from a systematic review and meta-analysis Environmental Sciences CHEMOSPHERE 8.943 321 / 10.1016/j.chemosphere.2023.138139 48 Lai,Yongxing;Lin,Xin;Wu,Lijuan;Zhao,Yinan;Lin,Fan;Lin,Chunjin;Lin,Han;Chen,Manli Integration of bulk RNA sequencing and single-cell analysis reveals a global landscape of DNA damage response in the immune environment of Alzheimer's disease Immunology FRONTIERS IN IMMUNOLOGY 8.786 14 / 10.3389/fimmu.2023.1115202 49 Lai,Jinqing;Wu,Zhe;Zeng,Yile;Lin,Weibin;Chen,Xiangrong;Chen,Genwang;Yu,Shaoyang;Huang,Rongfu;Fan,Chunmei PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following experimental subarachnoid hemorrhage Immunology FRONTIERS IN IMMUNOLOGY 8.786 14 / 10.3389/fimmu.2023.1105973 50 Li,Shuqun;Wu,Junyi;Wu,Jiayi;Fu,Yangkai;Zeng,Zhenxin;Li,Yinan;Li,Han;Yan,Maolin Prediction of early treatment response to the combination therapy of TACE plus lenvatinib and anti-PD-1 antibody immunotherapy for unresectable hepatocellular carcinoma: Multicenter retrospective study Immunology FRONTIERS IN IMMUNOLOGY 8.786 14 / 10.3389/fimmu.2023.1109771 51 Wang,Baoshan;Li,Dazhou;Wang,Wen;Jiang,Chuanshen;Zeng,Dehua Case report: Advanced primary squamous cell carcinoma in the periampullary area with upregulation of programmed cell death-ligand 1 expression and response to sintilimab immunotherapy Immunology FRONTIERS IN IMMUNOLOGY 8.786 14 / 10.3389/fimmu.2023.1086760 52 Zhang,Yu;Ye,Chenjing;Zhu,Haojie;Chen,Shaozhen;Weng,Yingxi;Ren,Jinhua;Luo,Xiaofeng;Zheng,Jing;Zheng,Xiaoyun;Li,Jing;Lan,Lingqiong;Xie,Yongxin;Hu,Jianda;Yang,Ting Association of iKIR-mismatch model and donor aKIRs with better outcome in haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia Immunology FRONTIERS IN IMMUNOLOGY 8.786 13 / 10.3389/fimmu.2022.1091188 53 Mei,Jian;Ding,Haiqi;Zhang,Wenming;Fang,Xinyu;Wei,Penghui Impact of ankylosing spondylitis on stroke limited to specific subtypes: Evidence from Mendelian randomization study Immunology FRONTIERS IN IMMUNOLOGY 8.786 13 / 10.3389/fimmu.2022.1095622 54 Li,Deyu Cross-talk between cuproptosis and ferroptosis regulators defines the tumor microenvironment for the prediction of prognosis and therapies in lung adenocarcinoma Immunology FRONTIERS IN IMMUNOLOGY 8.786 13 / 10.3389/fimmu.2022.1029092 55 Weng,Danfeng;Chen,Xiangna;He,Long;Lin,Huangfeng;Wang,Shenglin;Ji,Daihan;Lu,Shuting;Ao,Lu Integrated analysis of transcription factor-mRNA-miRNA regulatory network related to immune characteristics in medullary thyroid carcinoma Immunology FRONTIERS IN IMMUNOLOGY 8.786 13 / 10.3389/fimmu.2022.1055412 56 Chen,Li;Wang,Shousen;Lin,Yinghong;Chen,Qizuan;Feng,Tianshun Systemic immune inflammation index and peripheral blood carbon dioxide concentration at admission predict poor prognosis in patients with severe traumatic brain injury Immunology FRONTIERS IN IMMUNOLOGY 8.786 13 / 10.3389/fimmu.2022.1034916 57 Huang,Hongbiao;Yang,Fang;Chen,Qiaobin;Dong,Jinfeng;You,Guoping The role of FOXO4/NFAT2 signaling pathway in dysfunction of human coronary endothelial cells and inflammatory infiltration of vasculitis in Kawasaki disease Immunology FRONTIERS IN IMMUNOLOGY 8.786 13 / 10.3389/fimmu.2022.1090056 58 Yu,Xueping;Shen,Zhiqing;Ren,Lan;Su,Zhijun Granulocytic myeloid-derived suppressor cells increase infection risk via the IDO/IL-10 pathway in patients with hepatitis B virus-related liver failure Immunology FRONTIERS IN IMMUNOLOGY 8.786 13 / 10.3389/fimmu.2022.966514 59 Xu,Weihong SARS-CoV-2 induces cytokine storm hyperinflammatory responses in RA patients through pyroptosis FRONTIERS IN IMMUNOLOGY   English Article      SARS-CoV-2; COVID-19; rheumatoid arthritis; pyroptosis; caspase-1; minocycline NLRP3 INFLAMMASOME ACTIVATION; PATTERN-RECOGNITION RECEPTORS; RHEUMATOID-ARTHRITIS; GASDERMIN D; CELL-DEATH; MOLECULAR-MECHANISMS; PORE FORMATION; MINOCYCLINE; COVID-19; CASPASES BackgroundThe coronavirus disease (COVID-19) is a pandemic disease that threatens worldwide public health, and rheumatoid arthritis (RA) is the most common autoimmune disease. COVID-19 and RA are each strong risk factors for the other, but their molecular mechanisms are unclear. This study aims to investigate the biomarkers between COVID-19 and RA from the mechanism of pyroptosis and find effective disease-targeting drugs. MethodsWe obtained the common gene shared by COVID-19, RA (GSE55235), and pyroptosis using bioinformatics analysis and then did the principal component analysis(PCA). The Co-genes were evaluated by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and ClueGO for functional enrichment, the protein-protein interaction (PPI) network was built by STRING, and the k-means machine learning algorithm was employed for cluster analysis. Modular analysis utilizing Cytoscape to identify hub genes, functional enrichment analysis with Metascape and GeneMANIA, and NetworkAnalyst for gene-drug prediction. Network pharmacology analysis was performed to identify target drug-related genes intersecting with COVID-19, RA, and pyroptosis to acquire Co-hub genes and construct transcription factor (TF)-hub genes and miRNA-hub genes networks by NetworkAnalyst. The Co-hub genes were validated using GSE55457 and GSE93272 to acquire the Key gene, and their efficacy was assessed using receiver operating curves (ROC); SPEED2 was then used to determine the upstream pathway. Immune cell infiltration was analyzed using CIBERSORT and validated by the HPA database. Molecular docking, molecular dynamics simulation, and molecular mechanics-generalized born surface area (MM-GBSA) were used to explore and validate drug-gene relationships through computer-aided drug design. ResultsCOVID-19, RA, and pyroptosis-related genes were enriched in pyroptosis and pro-inflammatory pathways(the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome complex, death-inducing signaling complex, regulation of interleukin production), natural immune pathways (Network map of SARS-CoV-2 signaling pathway, activation of NLRP3 inflammasome by SARS-CoV-2) and COVID-19-and RA-related cytokine storm pathways (IL, nuclear factor-kappa B (NF-kappa B), TNF signaling pathway and regulation of cytokine-mediated signaling). Of these, CASP1 is the most involved pathway and is closely related to minocycline. YY1, hsa-mir-429, and hsa-mir-34a-5p play an important role in the expression of CASP1. Monocytes are high-caspase-1-expressing sentinel cells. Minocycline can generate a highly stable state for biochemical activity by docking closely with the active region of caspase-1. ConclusionsCaspase-1 is a common biomarker for COVID-19, RA, and pyroptosis, and it may be an important mediator of the excessive inflammatory response induced by SARS-CoV-2 in RA patients through pyroptosis. Minocycline may counteract cytokine storm inflammation in patients with COVID-19 combined with RA by inhibiting caspase-1 expression. [Zheng, Qingcong; Lin, Rongjie; Lv, Qi; Wang, Wanming] 900th Hosp Joint Logist Support Force, Dept Orthoped, Fuzhou, Peoples R China; [Chen, Yuchao] Fujian Prov Hosp South Branch, Dept Paediat, Fuzhou, Peoples R China; [Zhang, Jin] Univ Mississippi Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS USA; [Zhai, Jingbo] Inner Mongolia Minzu Univ, Key Lab Zoonose Prevent & Control Univ Inner Mongo, Med Coll, Tongliao, Peoples R China; [Xu, Weihong] Fujian Med Univ, Affiliated Hosp 1, Dept Orthoped, Fuzhou, Peoples R China University of Mississippi; University of Mississippi Medical Center; Fujian Medical University Wang, WM (通讯作者)，900th Hosp Joint Logist Support Force, Dept Orthoped, Fuzhou, Peoples R China.; Xu, WH (通讯作者)，Fujian Med Univ, Affiliated Hosp 1, Dept Orthoped, Fuzhou, Peoples R China. xuweihong815@126.com; wangwm93@126.com       240 0 0 3 3 FRONTIERS MEDIA SA LAUSANNE AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND 1664-3224   FRONT IMMUNOL Front. 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Pharmacology & Pharmacy PHYTOMEDICINE 6.656 110 / 10.1016/j.phymed.2022.154632 92 Li,Lijun;Zou,Yulian;Lan,Hailin;Zhang,Qiuyu;Wang,Xuewen;Yao,Hong;Lin,Xinhua;Chen,Bing Delicaflavone reactivates anti-tumor immune responses by abrogating monocytic myeloid cell-mediated immunosuppression Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy PHYTOMEDICINE 6.656 108 / 10.1016/j.phymed.2022.154508 93 Wang,Chunhua;Chen,Quan;Chen,Meiqing;Guo,Sizhen;Hou,Ping;Zou,Yulian;Wang,Jun;He,Bailin;Zhang,Qiuyu;Chen,Lieping;Luo,Liqun Interaction of glioma-associated microglia/macrophages and anti-PD1 immunotherapy Oncology; Immunology CANCER IMMUNOLOGY IMMUNOTHERAPY 6.63 / / 10.1007/s00262-022-03358-3 94 Yu,Guoyu;Lin,Yuan;Dai,Hanhao;Xu,Jie Association between serum 25-hydroxyvitamin D and osteoarthritis: A national population-based analysis of NHANES 2001-2018 Nutrition & Dietetics FRONTIERS IN NUTRITION 6.59 10 / 10.3389/fnut.2023.1016809 95 Li,Haibo Relationships for vitamin D with childhood height growth velocity and low bone mineral density risk Nutrition & Dietetics FRONTIERS IN NUTRITION 6.59 10 / 10.3389/fnut.2023.1081896 96 Tian,Pan;Xiong,Jialing;Wu,Wanxia;Chen,Aizhen;Wu,Aiyu;Shi,Shanshan;Chen,Kaihong;Chen,Weihua;Liao,Ying Impact of the malnutrition on mortality in Rheumatoid arthritis patients: A cohort study from NHANES 1999-2014 Nutrition & Dietetics FRONTIERS IN NUTRITION 6.59 9 / 10.3389/fnut.2022.993061 97 Yang,Mei;Yu,Jiami;Wang,Xiaojie;Guo,Zengqing De novo Creation and Assessment of a Prognostic Fat-Age-Inflammation Index FAIN in Patients With Cancer: A Multicenter Cohort Study FRONTIERS IN NUTRITION   English Article      cancer; malnutrition; mortality; fat mass; inflammation ESPEN GUIDELINES; MALNUTRITION; STATISTICS; NUTRITION; PREVALENCE; VALIDATION; SARCOPENIA; SURVIVAL; SUPPORT; PNI Background and AimsMalnutrition is highly prevalent and is related to multiple impaired clinical outcomes in cancer patients. This study aimed to de novo create an objective, nutrition-related index specially for prognostic purposes in oncology populations. MethodsWe performed a multicenter cohort study including 14,134 cancer patients. The prognostic impact for each baseline characteristic was estimated by calculating Harrell's C-index. The optimal parameters reflecting the nutritional and inflammatory impact on patients' overall survival were selected to develop the fat-age-inflammation (FAIN) index. The associations of the FAIN with the nutritional status, physical performance, quality of life, short-term outcomes and mortality of patients were comprehensively evaluated. Independent external validation was performed to further assess the prognostic value of the FAIN. ResultsThe study enrolled 7,468 men and 6,666 women with a median age of 57 years and a median follow-up of 42 months. The FAIN index was defined as: (triceps skinfold thickness + albumin) / [age + 5 x (neutrophil count/lymphocyte count)]. There were significant associations of the FAIN with the nutritional status, physical performance, quality of life and short-term outcomes. The FAIN also showed better discrimination performance than the Nutritional Risk Index, the Prognostic Nutritional Index and the Controlling Nutritional Status index (all P < 0.05). In multivariable-adjusted models, the FAIN was independently associated with a reduced death hazard both as a continuous variable (HR = 0.57, 95%CI = 0.47-0.68) and per one standard deviation (HR = 0.83, 95%CI = 0.78-0.88). External validation in a multicenter lung cancer cohort (n = 227) further confirmed the prognostic value of the FAIN. ConclusionsThis study created and assessed the prognostic FAIN index, which might act as a feasible option to monitor the nutritional status and help develop intervention strategies to optimize the survival outcomes of cancer patients. [Yin, Liangyu; Lin, Xin; Li, Na; Fan, Yang; Zhang, Ling; Liu, Jie; Chong, Feifei; Xu, Hongxia] Third Mil Med Univ, Army Med Univ, Daping Hosp, Dept Clin Nutr, Chongqing, Peoples R China; [Yin, Liangyu] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Inst Hepatopancreatobiliary Surg, Chongqing, Peoples R China; [Song, Chunhua] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol, Zhengzhou, Peoples R China; [Cui, Jiuwei; Wang, Chang; Liang, Tingting; Liu, Xiangliang; Deng, Li; Li, Wei] Jilin Univ, Hosp 1, Canc Ctr, Changchun, Peoples R China; [Yang, Mei; Yu, Jiami; Wang, Xiaojie; Guo, Zengqing] Fujian Med Univ, Fujian Canc Hosp, Dept Med Oncol, Canc Hosp, Fuzhou, Peoples R China; [Liu, Xing; Yang, Shoumei; Zuo, Zheng; Li, Suyi] Univ Sci & Technol China, Anhui Prov Canc Hosp, Dept Nutr & Metab Oncol, Affiliated Hosp 1, Hefei, Peoples R China; [Yuan, Kaitao; Yu, Miao] Sun Yat Sen Univ, Affiliated Hosp 1, Ctr Gastrointestinal Surg, Guangzhou, Peoples R China; [Cong, Minghua] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr Canc Hosp, Dept Comprehens Oncol, Beijing, Peoples R China; [Li, Zengning] Hebei Med Univ, Dept Clin Nutr, Hosp 1, Shijiazhuang, Peoples R China; [Weng, Min] Kunming Med Univ, Dept Clin Nutr, Affiliated Hosp 1, Kunming, Peoples R China; [Yao, Qinghua] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Integrated Chinese & Western Med, Canc Hosp, Hangzhou, Peoples R China; [Jia, Pingping; Shi, Hanping] Capital Med Univ, Beijing Shijitan Hosp, Dept Gastrointestinal Surg, Beijing, Peoples R China; [Jia, Pingping; Shi, Hanping] Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Nutr, Beijing, Peoples R China Army Medical University; Army Medical University; Zhengzhou University; Jilin University; Fujian Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Sun Yat Sen University; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Hebei Medical University; Kunming Medical University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang Cancer Hospital; Capital Medical University; Capital Medical University Xu, HX (通讯作者)，Third Mil Med Univ, Army Med Univ, Daping Hosp, Dept Clin Nutr, Chongqing, Peoples R China.; Li, W (通讯作者)，Jilin Univ, Hosp 1, Canc Ctr, Changchun, Peoples R China.; Shi, HP (通讯作者)，Capital Med Univ, Beijing Shijitan Hosp, Dept Gastrointestinal Surg, Beijing, Peoples R China.; Shi, HP (通讯作者)，Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Nutr, Beijing, Peoples R China. liwei66@jlu.edu.cn; shihp@ccmu.edu.cn; hx_xu2015@163.com Yin, Liangyu/AAE-4982-2021; Liu, Xiangliang/HDO-7937-2022 Yin, Liangyu/0000-0001-8876-2680;      49 1 1 1 5 FRONTIERS MEDIA SA LAUSANNE AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND 2296-861X   FRONT NUTR Front. 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PHARMACOLOGY 5.988 13 / 10.3389/fphar.2022.991238 152 Lian,Zhiwei;Yu,Hui;Zhang,Gong;Wu,Fan;Liu,Jian;Chen,Chuanben Factors associated with the uptake of biosimilars for breast cancer treatment from the perspectives of physicians and patients-Evidence from China Pharmacology & Pharmacy FRONTIERS IN PHARMACOLOGY 5.988 13 / 10.3389/fphar.2022.1044798 153 Lu,Lihong;Fang,Mingcheng Performance of novel 3D printing tools in removing coronary-artery calcification tissue Engineering, Biomedical BIO-DESIGN AND MANUFACTURING 5.887 / / 10.1007/s42242-022-00228-w 154 Chen,Ya-Fang;Chen,Chun-Nuan;Yang,Mei-Li;Zhang,Jin-Yin;Li,Yuan-zhe;Wang,Yi Stroke risk study based on deep learning-based magnetic resonance imaging carotid plaque automatic segmentation algorithm Cardiac & Cardiovascular Systems FRONTIERS IN CARDIOVASCULAR MEDICINE 5.846 10 / 10.3389/fcvm.2023.1101765 155 Xie,Lin-Feng;He,Jian;Wu,Qing-Song;Qiu,Zhi-Huang;Jiang,De-Bin;Gao,Hang-Qi;Chen,Liang-wan Do obese patients with type A aortic dissection benefit from total arch repair through a partial upper sternotomy? Cardiac & Cardiovascular Systems FRONTIERS IN CARDIOVASCULAR MEDICINE 5.846 10 / 10.3389/fcvm.2023.1086738 156 Zheng,Xiaoxin;Guan,Qing;Lin,Xiuquan Changing trends of the disease burden of non-rheumatic valvular heart disease in China from 1990 to 2019 and its predictions: Findings from global burden of disease study Cardiac & Cardiovascular Systems FRONTIERS IN CARDIOVASCULAR MEDICINE 5.846 9 / 10.3389/fcvm.2022.912661 157 Xiao,Hui-Jun;Zhan,A-Lai;Huang,Qing-Wen;Huang,Rui-Gang;Lin,Wei-Hua Evaluation of the aorta in infants with simple or complex coarctation of the aorta using CT angiography Cardiac & Cardiovascular Systems FRONTIERS IN CARDIOVASCULAR MEDICINE 5.846 9 / 10.3389/fcvm.2022.1034334 158 Zhang,Xuehua Novel variants of seryl-tRNA synthetase resulting in HUPRA syndrome featured in pulmonary hypertension Cardiac & Cardiovascular Systems FRONTIERS IN CARDIOVASCULAR MEDICINE 5.846 9 / 10.3389/fcvm.2022.1058569 159 Huang,Jiang-Shan;Chen,Yu-Kun;Lin,Shi-Hao;Chen,Qiang;Cao,Hua;Zheng,Yi-Rong A comparison of the changes in serum lactate between surgical repair and transthoracic device closure of ventricular septal defects in pediatric patients Cardiac & Cardiovascular Systems FRONTIERS IN CARDIOVASCULAR MEDICINE 5.846 9 / 10.3389/fcvm.2022.961997 160 Xiao,Jun Total Arch Replacement With Frozen Elephant Trunk Using a NEW Brain-Heart-First Strategy for Acute DeBakey Type I Aortic Dissection Can Be Performed Under Mild Hypothermia (>= 30 degrees C) With Satisfactory Outcomes FRONTIERS IN CARDIOVASCULAR MEDICINE   English Article      total arch replacement; frozen elephant trunk; mild hypothermia; heart-brain-first; acute DeBakey type I aortic dissection CEREBRAL PERFUSION; REPAIR; SURGERY; HYBRID; GRAFT BackgroundTotal arch replacement (TAR) with Frozen elephant trunk (FET) treatment of acute DeBakey type I aortic dissection (ADIAD) is complicated, carries a high complication/mortality risk and remains controversial on the optimal hypothermic level, cerebral perfusion and visceral organ protection strategy. We developed a new strategy named Brain-Heart-first in which the surgical procedures and the management of cardiac perfusion/cerebral protection during Cardiopulmonary bypass (CPB) were redesigned, and TAR with FET technique can be performed under mild hypothermia with satisfactory outcomes. ObjectiveOur aims were to describe a new surgical strategy under mild hypothermia (>= 30 degrees C) for the treatment of ADIAD and to report the operative outcomes of 215 patients. MethodsWe conducted a retrospective analysis of 215 consecutive cases of ADIAD treated with our new strategy. ResultsThe durations of CPB, aortic cross-clamping, antegrade cerebral perfusion, operation, mechanical ventilation support, and Intensive Care Unit stay were 139.7 +/- 52.3 min, 55.6 +/- 27.4 min, 14.1 +/- 3.1 min, 6.0 +/- 1.7 h, 40.0 h and 4.0 d, respectively. The 30-day mortality was 9.8%, with cerebral stroke occurring in nine patients (4.2%), paraplegia in one patient (0.5%) and postoperative renal injury requiring dialysis in 21 patients (9.8%). The blood transfusion of red blood cells and fresh frozen plasma during surgery and the first 24 h after surgery was 4.0 u and 200.0 ml, respectively. ConclusionsThe Brain-Heart-first strategy can be widely used with low technical and resource requirements and provides a safe alternative for conventional TAR with FET technique in ADIAD patients with satisfactory operative results. [Shen, Kangjun; Tan, Ling; Tang, Hao; Zhou, Xinmin; Xiao, Jun; Xie, Dongshu; Li, Jingyu; Chen, Yichuan] Cent South Univ, Dept Cardiovasc Surg, Xiangya Hosp 2, Changsha, Peoples R China; [Xiao, Jun] Fujian Med Univ, Union Hosp, Dept Cardiac Surg, Fuzhou, Peoples R China Central South University; Fujian Medical University Tang, H (通讯作者)，Cent South Univ, Dept Cardiovasc Surg, Xiangya Hosp 2, Changsha, Peoples R China. dr.tanghao@csu.edu.cn Li, Jingyu/GSD-1924-2022; LI, Jing/HNB-5575-2023; Li, Jing/GYU-5036-2022  Key Research and Development Program of Hunan Province [2019SK2022] Key Research and Development Program of Hunan Province Funding This study was funded by the Key Research and Development Program of Hunan Province (No. 2019SK2022).  26 0 0 1 5 FRONTIERS MEDIA SA LAUSANNE AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND 2297-055X   FRONT CARDIOVASC MED Front. 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Li,Yuan-Zhe Bone age recognition based on mask R-CNN using xception regression model Physiology FRONTIERS IN PHYSIOLOGY 4.755 14 / 10.3389/fphys.2023.1062034 259 Chen,Ting Detection of sarcopenia using deep learning-based artificial intelligence body part measure system (AIBMS) Physiology FRONTIERS IN PHYSIOLOGY 4.755 14 / 10.3389/fphys.2023.1092352 260 Ke,Zhi-Bin;You,Qi;Xue,Yu-Ting;Sun,Jiang-Bo;Chen,Jia-Yin;Liu,Wen-Qi;Wei,Yong;Zheng,Qing-Shui;Li,Xiao-Dong;Xue,Xue-Yi;Xu,Ning Body composition parameters were associated with response to abiraterone acetate and prognosis in patients with metastatic castration-resistant prostate cancer Oncology CANCER MEDICINE 4.711 / / 10.1002/cam4.5640 261 Huang,Zhijian;Chen,Jian;Lei,Wen;Zhang,Fuqing miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134 Genetics & Heredity CURRENT GENE THERAPY 4.676 23 1 60-71 262 Zhang,Xing;Yang,Longkun Independent and interactive effect of sedentary time and physical activity on risk of all-cause mortality: A prospective cohort study Sport Sciences SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 4.645 / / 10.1111/sms.14346 263 Fu,Jun;Lai,Zisen;Lin,Kongying;Fang,Guoxu;Ding,Zongren;Zeng,Yongyi A novel preoperative inflammation score system established for postoperative prognosis predicting of intrahepatic cholangiocarcinoma Oncology BMC CANCER 4.638 23 1 10.1186/s12885-023-10668-x 264 Fei,Zhaodong;Hong,Huiling;Xu,Ting;Xu,Yiying;Chen,Jiawei;Qiu,Xiufang;Ding,Jianming;Feng,Ye;Huang,Chaoxiong;Li,Li;Li,Mengying;Chen,Chuanben Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma Oncology BMC CANCER 4.638 23 1 10.1186/s12885-023-10641-8 265 Wang,Changyuan;Wang,Yang;Xiao,Wangchuan;Chen,Xiaohua;Li,Renfu;Shen,Zhiyong;Lu,Fengchun Carboxylated superparamagnetic Fe3O4 nanoparticles modified with 3-amino propanol and their application in magnetic resonance tumor imaging Oncology BMC CANCER 4.638 23 1 10.1186/s12885-023-10514-0 266 Kang,Deyong;Guan,Guoxian;Zhou,Yongjian Rapid and label-free detection of gastrointestinal stromal tumor via a combination of two-photon microscopy and imaging analysis Oncology BMC CANCER 4.638 23 1 10.1186/s12885-023-10520-2 267 Wang,Xuezhen;Li,Xiaoxia;Wu,Yufan;Hong,Jinsheng;Zhang,Mingwei The prognostic significance of tumor-associated neutrophils and circulating neutrophils in glioblastoma (WHO CNS5 classification) Oncology BMC CANCER 4.638 23 1 10.1186/s12885-022-10492-9 268 Liao,Cheng-Yu;Wang,Dan-Feng;Jiang,Bin-Hua;Huang,Long;Lin,Tian-Sheng;Qiu,Fu-Nan;Zhou,Song-Qiang;Wang,Yao-Dong;Zheng,Xiao-Chun;Tian,Yi-Feng;Chen,Shi Optimization of a laparoscopic procedure for advanced intrahepatic cholangiocarcinoma based on the concept of waiting time: a preliminary report BMC CANCER   English Article      Intrahepatic cholangiocarcinoma; Laparoscopic; Lymph node dissection; Optimization; Hemihepatectomy OPEN LIVER RESECTION; PROPENSITY; SCORE; LYMPHADENECTOMY; OUTCOMES; COHORT; HEMIHEPATECTOMY; FEASIBILITY; HEPATECTOMY; MULTICENTER Introduction Clinicians increasingly perform laparoscopic surgery for intrahepatic cholangiocarcinoma (ICC). However, this surgery can be difficult in patients with advanced-stage ICC because of the complicated procedures and difficulty in achieving high-quality results. We compared the effects of a three-step optimized procedure with a traditional procedure for patients with advanced-stage ICC. Methods Forty-two patients with advanced-stage ICC who received optimized laparoscopic hemihepatectomy with lymph node dissection (LND, optimized group) and 84 propensity score-matched patients who received traditional laparoscopic hemihepatectomy plus LND (traditional group) were analyzed. Surgical quality, disease-free survival (DFS), and overall survival (OS) were compared. Results The optimized group had a lower surgical bleeding score (P = 0.038) and a higher surgeon satisfaction score (P = 0.001). Blood loss during hepatectomy was less in the optimized group (190 vs. 295 mL, P < 0.001). The optimized group had more harvested LNs (12.0 vs. 8.0, P < 0.001) and more positive LNs (8.0 vs. 5.0, P < 0.001), and a similar rate of adequate LND (88.1% vs. 77.4%, P = 0.149). The optimized group had longer median DFS (9.0 vs. 7.0 months, P = 0.018) and median OS (15.0 vs. 13.0 months, P = 0.046). In addition, the optimized group also had a shorter total operation time (P = 0.001), shorter liver resection time (P = 0.001), shorter LND time (P < 0.001), shorter hospital stay (P < 0.001), and lower incidence of total morbidities (14.3% vs. 36.9%, P = 0.009). Conclusions Our optimization of a three-step laparoscopic procedure for advanced ICC was feasible, improved the quality of liver resection and LND, prolonged survival, and led to better intraoperative and postoperative outcomes. [Liao, Cheng-Yu; Wang, Dan-Feng; Jiang, Bin-Hua; Huang, Long; Lin, Tian-Sheng; Qiu, Fu-Nan; Zhou, Song-Qiang; Wang, Yao-Dong; Zheng, Xiao-Chun; Tian, Yi-Feng; Chen, Shi] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou, Peoples R China; [Liao, Cheng-Yu; Jiang, Bin-Hua; Huang, Long; Lin, Tian-Sheng; Qiu, Fu-Nan; Zhou, Song-Qiang; Wang, Yao-Dong; Tian, Yi-Feng; Chen, Shi] Fujian Prov Hosp, Dept Hepatobiliary Pancreat Surg, Fuzhou 350001, Peoples R China; [Wang, Dan-Feng; Zheng, Xiao-Chun] Fujian Prov Hosp, Dept Anesthesiol, Fuzhou 350001, Peoples R China; [Zheng, Xiao-Chun] Fujian Emergency Med Ctr, Fujian Prov Coconstruct Lab Belt & Rd, Fujian Prov Key Lab Emergency Med, Fujian Prov Key Lab Crit Med, Fuzhou, Peoples R China Fujian Medical University; Fujian Provincial Hospital; Fujian Provincial Hospital Zheng, XC; Tian, YF; Chen, S (通讯作者)，Fujian Med Univ, Shengli Clin Med Coll, Fuzhou, Peoples R China.; Tian, YF; Chen, S (通讯作者)，Fujian Prov Hosp, Dept Hepatobiliary Pancreat Surg, Fuzhou 350001, Peoples R China.; Zheng, XC (通讯作者)，Fujian Prov Hosp, Dept Anesthesiol, Fuzhou 350001, Peoples R China.; Zheng, XC (通讯作者)，Fujian Emergency Med Ctr, Fujian Prov Coconstruct Lab Belt & Rd, Fujian Prov Key Lab Emergency Med, Fujian Prov Key Lab Crit Med, Fuzhou, Peoples R China. fjslyymzk@126.com; yifengtian123@126.com; wawljwalj@163.com   Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare [2021(60)]; Fujian Youth Talent Support Program [2018(05)]; Youth Scientific Research Project of Fujian Provincial Health Commission [2020QNA005]; key Clinical Specialty Discipline Construction Program of Fujian, P.R.C. Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare; Fujian Youth Talent Support Program; Youth Scientific Research Project of Fujian Provincial Health Commission; key Clinical Specialty Discipline Construction Program of Fujian, P.R.C. This work was supported by the Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare (No.2021(60), to Shi Chen), the Fujian Youth Talent Support Program (No.2018(05), to Shi Chen) and the Youth Scientific Research Project of Fujian Provincial Health Commission (No. 2020QNA005, to Dan-Feng Wang). This work was sponsored by key Clinical Specialty Discipline Construction Program of Fujian, P.R.C.  62 0 0 0 0 BMC LONDON CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND  1471-2407  BMC CANCER BMC Cancer NOV 28 2022 22 1       1222 10.1186/s12885-022-10323-x http://dx.doi.org/10.1186/s12885-022-10323-x   14 Oncology Science Citation Index Expanded (SCI-EXPANDED) Oncology 6N4TW 36443693 Green Published, gold   2023-03-28 WOS:000889551200007 Oncology BMC CANCER 4.638 22 1 10.1186/s12885-022-10323-x 269 Fang,Jiaoning;Lin,Yan;Pan,Mian;Lin,Yingying;Chen,Zhiwei The Association of Inflammatory Markers with Maternal-Neonatal Outcome After Cervical Cerclage Immunology JOURNAL OF INFLAMMATION RESEARCH 4.631 16 / 245-255 270 Zhang,Sheng Legumain inhibitor prevents breast cancer bone metastasis by attenuating osteoclast differentiation and function Endocrinology & Metabolism BONE 4.626 169 / 10.1016/j.bone.2023.116680 271 Wang,Changsheng;Chen,Rongsheng;Zhu,Xitian;Zhang,Xiaobo;Lian,Nancheng METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m6A level of SIRT1 mRNA Endocrinology & Metabolism BONE 4.626 168 / 10.1016/j.bone.2022.116652 272 Shen,Minghong Efficacy of autologous platelet-rich plasma in preventing adhesion reformation following hysteroscopic adhesiolysis: a randomized controlled trial Obstetrics & Gynecology; 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Toxicology; Water Resources ENVIRONMENTAL TOXICOLOGY 4.109 38 4 941-949 310 Cao,Xueqiong;Cai,Hongfu A cost-effectiveness analysis of first-line toripalimab plus chemotherapy in advanced nonsquamous non-small cell lung cancer in China Pharmacology & Pharmacy EXPERT REVIEW OF CLINICAL PHARMACOLOGY 4.108 / / 10.1080/17512433.2023.2188194 311 Lin,Jianxian;Huang,Changming;Hong,Qingqi CT-based radiomics nomogram for differentiating gastric hepatoid adenocarcinoma from gastric adenocarcinoma: a multicentre study Gastroenterology & Hepatology EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY 4.095 17 2 205-214 312 He,Raoli;Zhang,Jian;Huang,Tianwen;Cai,Guoen;Zou,Zhangyu;Ye,Qinyong Novel mutations in the ABCD1 gene caused adrenomyeloneuropathy in the Chinese population Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 14 / 10.3389/fneur.2023.1126729 313 Wang,Zhiqiang The development of neurocritical care in China from the perspective of evaluation and treatment of critical neurological diseases Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 14 / 10.3389/fneur.2023.1114204 314 Liu,Tianqing;Gao,Zhenwen;Zhou,Jianjun;Lai,Xiaoyan;Chen,Xiaomei;Rao,Qiong;Guo,Dongbin;Zheng,Jinliang;Lin,Zhiqin;Lin,Fuxin;Lin,Yuanxiang Subdural evacuating port system with subdural thrombolysis for the treatment of chronic subdural hematoma in patients older than 80 years Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 14 / 10.3389/fneur.2023.1068829 315 Su,Shan-Shan;Li,Li-Ya;Wang,Yi;Li,Yuan-Zhe Stroke risk prediction by color Doppler ultrasound of carotid artery-based deep learning using Inception V3 and VGG-16 Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 14 / 10.3389/fneur.2023.1111906 316 Qiu,Weizhi;Liu,Chubin;Wang,Gang;Yang,Fuxing;Pan,Zhigang;Hu,Weipeng;Gao,Hongzhi Age-to-Glasgow Coma Scale score ratio predicts gastrointestinal bleeding in patients with primary intracerebral hemorrhage Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 14 / 10.3389/fneur.2023.1034865 317 Wang,Shousen Pituitary stalk changes on magnetic resonance imaging following pituitary adenoma resection using a transsphenoidal approach Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 14 / 10.3389/fneur.2023.1049577 318 Gao,Hong;Lin,Yuanxiang Identification of hub genes significantly linked to subarachnoid hemorrhage and epilepsy via bioinformatics analysis Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 14 / 10.3389/fneur.2023.1061860 319 Qiu,Xiansheng;Wang,Zhanxiang The compensatory mechanism and clinical significance of hydrocephalus after cranioplasty Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 13 / 10.3389/fneur.2022.1075137 320 Wu,Xuan;Ye,XiaoBin;Wang,Ning;Li,RunYun Reduced quality of life in myasthenia gravis patients: A study on 185 patients from China Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 13 / 10.3389/fneur.2022.1072861 321 Yi,Ting-yu;Wu,Yan-min;Lin,Ding-lai;Yang,Yu-yan;Pan,Zhi-nan;Zheng,Xiu-fen;Hong,Gan-ji;Wu,Mei-hua;Lin,Xiao-hui;Chen,Rong-cheng;Zeng,Lisan;Chen,Wen-huo Association of baseline core volume and early midline shift in acute stroke patients with a large ischaemic core Clinical Neurology; Neurosciences FRONTIERS IN NEUROLOGY 4.086 13 / 10.3389/fneur.2022.1077824 322 Yong,Binbin;Zhang,Yanyan;Xiao,Huimin Nursing home adjustment in China: mediating and moderating effects Geriatrics & Gerontology; Gerontology BMC GERIATRICS 4.07 23 1 10.1186/s12877-023-03758-9 323 Ghareeb,WaleedM.;Wang,Xiaojie;Chi,Pan;Zhao,Xiaozhen;Xie,Meirong The terminal line: a novel sign for the identification of distal mesorectum end during TME for rectal cancer GASTROENTEROLOGY REPORT   English Article      rectal cancer; total mesorectal excision; taTME; TAMIS; laparoscopy; robotic LOCAL RECURRENCE; EXCISION; SURVIVAL Background Although the clinical importance of complete, intact total mesorectal excision (TME) is the widely accepted standard for decreasing local recurrence of rectal cancer, the residual mesorectum still represents a significant component of resection margin involvement. This study aimed to use a visible intraoperative sign to detect the distal mesorectal end to ensure complete inclusion of the mesorectum and avoid unnecessary over-dissection. Methods The distal mesorectum end was investigated retrospectively through a review of 124 operative videos at the Union Hospital of Fujian Medical University (Fujian, China) and Cleveland Clinic (Ohio, USA) by two independent surgeons who were blinded to each other. Furthermore, 28 cadavers and 44 post-operative specimens were prospectively examined by hematoxylin and eosin (H&E) staining and Masson's staining to validate and confirm the findings of the retrospective part. Univariate and multivariate analyses were carried out to detect the independent factors that can affect the visualization of the distal mesorectal end. Results The terminal line (TL) is the distal mesorectal end of the transabdominal and transanal TME (taTME) and appears as a remarkable pearly white fascial structure extending posteriorly from 2 to 10 o'clock. Histopathological examination revealed that the fascia propria of the rectum merges with the presacral fascia at the TL, beyond which the mesorectum ends, with no further downward extension. In the retrospective observation, the TL was seen in 56.6% of transabdominal TME and 56.0% of taTME operations. Surgical approach and tumor distance from the anal verge were the independent variables that directly influenced the detection of the TL (P = 0.03 and P = 0.01). Conclusion The TL is a visible sign where the transabdominal TME should end and the taTME should begin. Recognition of the mesorectal end may impact the certainty of complete mesorectum inclusion. Further clinical trials are needed to confirm the preliminary findings. [Ghareeb, Waleed M.; Wang, Xiaojie; Chi, Pan] Fujian Med Univ, Dept Colon & Rectal Surg, Union Hosp, 29 Xin Quan Rd, Fuzhou 350001, Fujian, Peoples R China; [Ghareeb, Waleed M.] Suez Canal Univ, Fac Med, Dept Surg, Ismailia, Egypt; [Shawki, Sherief] Mayo Clin, Dept Colon & Rectal Surg, 200 1st St SW, Rochester, MN 55905 USA; [Zhao, Xiaozhen] Fujian Med Univ, Lab Clin Appl Anat, Fuzhou, Fujian, Peoples R China; [Xie, Meirong] Fujian Med Univ, Basic Med Coll, Fuzhou, Fujian, Peoples R China; [Emile, Sameh H.] Cleveland Clin Florida, Dept Colorectal Surg, Weston, FL USA; [Emile, Sameh H.] Mansoura Univ Hosp, Gen Surg Dept, Colorectal Surg Unit, Mansoura, Egypt Fujian Medical University; Egyptian Knowledge Bank (EKB); Suez Canal University; Mayo Clinic; Fujian Medical University; Fujian Medical University; Cleveland Clinic Foundation; Egyptian Knowledge Bank (EKB); Mansoura University Chi, P (通讯作者)，Fujian Med Univ, Dept Colon & Rectal Surg, Union Hosp, 29 Xin Quan Rd, Fuzhou 350001, Fujian, Peoples R China.; Shawki, S (通讯作者)，Mayo Clin, Dept Colon & Rectal Surg, 200 1st St SW, Rochester, MN 55905 USA. shawki.sherief@mayo.edu; chipan363@163.com   Chinese Scholarship Council (CSC) [2017DFH010880] Chinese Scholarship Council (CSC)(China Scholarship Council) This work was supported by the Chinese Scholarship Council (CSC) [grant number 2017DFH010880].  22 0 0 0 0 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 2052-0034   GASTROENTEROL REP Gastroenterol. 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Precise identification of the pulmonary intersegmental plane was needed for an optimal segmentectomy. Recently, (1) the ultra-high-definition 4K systems had claimed to overcome the lack of depth perception by secondary visual cues; (2) the no-waiting procedure was induced as an alternative and optimized method for identifying the plane. It was unclear whether combined ultra-high-definition 4K endovision systems with no-waiting technique in thoracoscopic segmentectomy could achieve an excellent result. A 68-year-old female patient was admitted into our hospital for occasional pulmonary nodule during her routine physical examination. The nodule is located between S8 and S9 segment, and was suspected to be an early-stage lung cancer. She underwent a thoracoscopic S89 complex segmentectomy using ultra-high-definition 4K endovision systems and no-waiting surgical technique. The intersegmental plane was clearly detected and easily treated by the endoscopic linear cutting staplers. The patient recovered well and was discharged without complications. Combining ultra-high-definition 4K endovision systems with no-waiting technique seems to be an optimal thoracoscopic segmentectomy approach for the management of lung cancers. [Liang, Mingqiang; Chen, Chun] Fujian Med Univ, Union Hosp, Dept Thorac Surg, Fuzhou, Peoples R China; [Liang, Mingqiang; Chen, Chun] Fujian Prov Univ, Fujian Med Univ, Key Lab Cardiothorac Surg, Fuzhou, Peoples R China; [Wang, Liang; Gao, Jiabin; Duan, Zhiliang; Xu, Jinhai; Wang, Yifang; Li, Shixin; Wang, Bowen] Guyuan Peoples Hosp, Dept Thorac Surg, Guyuan, Peoples R China; [Chen, Chun] Fujian Med Univ, Union Hosp, Dept Thorac Surg, 29 Xinquan Rd, Fuzhou 350001, Fujian, Peoples R China; [Wang, Bowen] Guyuan Peoples Hosp, Dept Thorac Surg, Jiulong Rd, Guyuan 756000, Ningxia, Peoples R China  Chen, C (通讯作者)，Fujian Med Univ, Union Hosp, Dept Thorac Surg, 29 Xinquan Rd, Fuzhou 350001, Fujian, Peoples R China.; Wang, BW (通讯作者)，Guyuan Peoples Hosp, Dept Thorac Surg, Jiulong Rd, Guyuan 756000, Ningxia, Peoples R China. wbwzh68@163.com; chenchun0209@fjmu.edu.cn       17 0 0 0 0 WILEY HOBOKEN 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 1759-7706 1759-7714  THORAC CANCER Thorac. 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Biotechnology & Applied Microbiology BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 2.724 / / 10.1002/bab.2424 466 Shi,Tengbin;Chen,Zhi;Wang,Zhenyu;Liu,Wenge;Li,Wenwen Prevalence of sleep disturbance in patients with cervical radiculopathy and an analysis of risk factors: a cross-sectional study Clinical Neurology; Orthopedics EUROPEAN SPINE JOURNAL 2.721 / / 10.1007/s00586-023-07655-y 467 Cai,Hongfu Cost-effectiveness analysis of pembrolizumab plus chemotherapy for patients with recurrent or metastatic cervical cancer in China Medicine, General & Internal; Medicine, Research & Experimental CURRENT MEDICAL RESEARCH AND OPINION 2.705 39 3 433-440 468 Chen,Rongsheng;Zhang,Xiaobo;Zhu,Xitian;Wang,Changsheng;Xu,Weihong Myricetin alleviated hydrogen peroxide-induced cellular senescence of nucleus pulposus cell through regulating SERPINE1 Orthopedics JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2.677 18 1 10.1186/s13018-022-03463-0 469 Xing,Yifeng;Liu,Chaowei;Li,Yan;Zhou,Lin;Wu,Dong Osteogenic effects of rapamycin on bone marrow mesenchymal stem cells via inducing autophagy Orthopedics JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2.677 18 1 10.1186/s13018-023-03616-9 470 Lin,Yuan;Dai,Hanhao;Song,Chao;Xu,Jie Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis Orthopedics JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2.677 18 1 10.1186/s13018-023-03538-6 471 Wang,Hui;Wu,Qiping;Zeng,Hao Acute gout attacks during the perioperative period and risk factors of recurrence after orthopedic surgery among untreated gout patients Orthopedics JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2.677 18 1 10.1186/s13018-023-03536-8 472 Chen,Li-Da;Huang,Ya-Ping;Xu,Qiao-Zhen;Chen,Ji-Zhi;Huang,Jie-Feng;Chen,Gong-Ping;Lin,Qi-Chang Nrf2 plays protective role during intermittent hypoxia-induced ferroptosis in rat liver (BRL-3A) cells Clinical Neurology; Respiratory System SLEEP AND BREATHING 2.655 / / 10.1007/s11325-023-02801-8 473 Chen,Xihang;Chen,Yuqing;Zhang,Rong;Ye,Shengnan;Lin,Zhongyang;Nian,Shengqing;Lin,Chang The biofilm characteristics and management of skin flap infection following cochlear implantation Otorhinolaryngology ACTA OTORHINOLARYNGOLOGICA ITALICA 2.618 42 4 372-379 474 Zhang,Xiaorong;Deng,Yuan;Qiu,Hongzhao;Yi,Sirui;Huang,Sijia;Hu,Shanwen Target-cycling synchronized rolling circle amplification strategy for biosensing Helicobacter pylori DNA Chemistry, Analytical LUMINESCENCE 2.613 / / 10.1002/bio.4457 475 Luo,Bi-Hua;Huang,Jian-Qing;Huang,Chun-Yu;Tian,Pan;Chen,Ai-Zhen;Wu,Wei-Hao;Ma,Xiao-Mei;Yuan,Yue-Xing;Yu,Lian Screening of Lymphoma Radiotherapy-Resistant Genes with CRISPR Activation Library Pharmacology & Pharmacy PHARMACOGENOMICS & PERSONALIZED MEDICINE 2.606 16 / 67-80 476 Hu,Jianda Safety and performance of the Spectra Optia apheresis system for white blood cell depletion in patients with elevated white blood cell counts Hematology JOURNAL OF CLINICAL APHERESIS 2.605 / / 10.1002/jca.22038 477 Chen,Yuwei;Sun,Yang;Deng,Zhibo Development of a risk model based on autophagy-related genes to predict survival and immunotherapy response in ovarian cancer Genetics & Heredity HEREDITAS 2.595 160 1 10.1186/s41065-023-00263-2 478 Mu,Yan;Lin,Xiuxia;Wu,Tingting Risk factors for delirium in advanced cancer patients: A systematic review and meta-analysis Oncology; Nursing EUROPEAN JOURNAL OF ONCOLOGY NURSING 2.588 62 / 10.1016/j.ejon.2023.102267 479 Liao,Zhenling;Wang,Chunfeng;Lan,Xiaoyan;Wu,Junjun;Yuan,Xiaohuan;Hu,Rong;Wu,Yong Never forsake-The positive experiences of dyadic coping among patients with acute leukemia and their spouses: A qualitative study Oncology; Nursing EUROPEAN JOURNAL OF ONCOLOGY NURSING 2.588 62 / 10.1016/j.ejon.2022.102262 480 Wu,Mengjing;Zhu,Yunyun;Lin,Xinyue;Yan,Xue;Mo,Peng;Ye,Ying;Zeng,Yanjing;Fu,Zhichao Prognostic nutritional index predicts the prognosis of patients with advanced esophageal cancer treated with immune checkpoint inhibitors: a retrospective cohort study Oncology; Gastroenterology & Hepatology JOURNAL OF GASTROINTESTINAL ONCOLOGY 2.587 / / 10.21037/jgo-23-48 481 Xue,Mengli;Chen,Jintong;Zheng,Weiwei;Liu,Yijuan;Lin,Yijuan;Wang,Chengdang Clinical characteristics and quality of life in patients with inflammatory bowel disease-associated anemia in Southeast China Gastroenterology & Hepatology EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 2.586 35 3 275-284 482 Liu,Canbin;Xie,Hongteng;Wei,Pei;Gong,Teng;Wu,Guohua;Xu,Zhaorong;Chen,Shun Clinical study of early rehabilitation training combined with negative pressure wound therapy for the treatment of deep partial-thickness hand burns Surgery FRONTIERS IN SURGERY 2.568 10 / 10.3389/fsurg.2023.1040407 483 Lin,Yong;Chen,Mei-fang;Chen,Liang-wan Anesthesia management of patients undergoing off-pump coronary artery bypass grafting: A retrospective study of single center Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1067750 484 Zheng,Shiyao;He,Hongxin;Yang,Chunkang;Lin,Nan;Wu,Qing Prognostic model construction and validation of esophageal cancer cellular senescence-related genes and correlation with immune infiltration Surgery FRONTIERS IN SURGERY 2.568 10 / 10.3389/fsurg.2023.1090700 485 Lin,Guang-Xun Comparison of oblique and transforaminal approaches to lumbar interbody fusion for lumbar degenerative disease: An updated meta-analysis Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1004870 486 Zhang,Minghua;Chen,Daohua;Wang,Qiang;Li,Ying;Huang,Shiming;Zhan,Peng;Lai,Jiajing;Jiang,Jianqing;Chen,Dongfeng Comparison of arthroscopic debridement and microfracture in the treatment of osteochondral lesion of talus Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1072586 487 Lin,Bin;Zhang,Yan-ping;Ye,Ying;Tang,Yi;Yang,ChangShun;Luo,Jie-wei;Gao,Mei-zhu;Fang,Zhu-ting A clinical analysis of intestinal mucosal necrosis and exfoliation induced by superior mesenteric vein thrombosis: A case report Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.988195 488 Zheng,Caihong;Wen,Yahui;Lin,Shunguo;Han,Hui;Xu,Chunsen A systematic review and meta-analysis of postmastectomy radiation therapy on prepectoral versus subpectoral breast reconstruction Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1019950 489 Chen,Xiaobin;Liu,Zhenwen;Zhou,Binbin;Fan,Zuyou;Zhao,Hu;Lin,Chen Application of femoral nerve block combined with modified swelling anesthesia in high ligation and stripping of great saphenous vein Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1086735 490 Chen,Xiaobin;Xu,Lei;Fan,Zuyou;Zhang,ZaiZhong;Lin,Chen Analysis of safety and efficacy of conservative treatment and endovascular treatment in patients with spontaneous isolated mesenteric artery dissection Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.944079 491 Hu,Hongxin;Lin,Mei;Wu,Xianwei;Lin,Yujin;Lin,Yijun;Chen,Guoli Intraoperative method of femoral head central measurement to prevent leg length discrepancy following hemiarthroplasty Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1055199 492 Su,Xiaoshan;Chen,Lin;Zhang,Yixiang;Lin,Xiaoping;Zhu,Zhixing;Zhang,Huaping;Wu,Weijing;Huang,Jiaming Large mediastinal mass diagnosed as Nocardia infection by endobronchial ultrasound-guided transbronchial needle aspiration in a ceramic worker: A case report Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.983074 493 Yan,Shouyi;Zhao,Wenxin;Wang,Bo;Zhang,Liyong;Cai,Shaojun;Lin,Lanqin An improved method of searching inferior parathyroid gland for the patients with papillary thyroid carcinoma based on a retrospective study Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.955855 494 Yang,Yuanfeng;Ding,Feng;Xu,Tianbao;Pan,Zhen;Zhuang,Jinfu;Liu,Xing;Guan,Guoxian Double-stapled anastomosis without dog-ears reduces the anastomotic leakage in laparoscopic anterior resection of rectal cancer: A prospective, randomized, controlled study FRONTIERS IN SURGERY   English Article      middle and high rectal cancer; anastomotic leakage; modified double-stapling technique; laparoscopic; anterior resection RISK-FACTORS; OPEN SURGERY; COLORECTAL ANASTOMOSIS; PATHOLOGICAL OUTCOMES; ASSISTED RESECTION; TRIAL; MULTICENTER; IMPACT; ILEOSTOMY; EXCISION BackgroundAnastomotic leakage (AL) is a major cause of postoperative morbidity and mortality in the treatment of colorectal cancer. The aim of this study was to investigate whether the resection of dog-ears in laparoscopic anterior resection of rectal cancer (called modified double-stapling technique, MDST) could reduce the rate of AL in patients with middle and high rectal cancer, as compared with the conventional double-stapling technique (DST). MethodsThe clinical data of 232 patients with middle and high rectal cancer were prospectively collected from September 2015 to October 2018. They were randomly divided into the MDST group (n = 116) and the DST group (n = 116) and the data were prospectively analyzed. Morbidity and AL rate were compared between the two groups. ResultsPatient demographics, tumor size, and time of first flatus were similar between the two groups. No difference was observed in the operation time between the two groups. The AL rate was significantly lower in the MDST group than in the DST group (3.4 vs. 11.2%, p = 0.032). The age and anastomotic technique were the factors associated with AL according to the multivariate analysis. The location of the AL in the DST group was further investigated, revealing that AL was in the same place as the dog-ears (11/13, 84.6%). ConclusionsOur prospective comparative study demonstrated that MDST have a better short-term outcome in reducing AL compared with DST. Therefore, this technique could be an alternative approach to maximize the benefit of laparoscopic anterior resection on patients with middle and high rectal cancer. The dog-ears create stapled corners potentially ischemic, since they represent the area with high incidence of AL.(NCT:02770911) [Yang, Yuanfeng; Ding, Feng; Xu, Tianbao; Pan, Zhen; Zhuang, Jinfu; Liu, Xing; Guan, Guoxian] Fujian Med Univ, Affiliated Hosp 1, Dept Colorectal Surg, Fuzhou, Peoples R China; [Guan, Guoxian] Fujian Med Univ, Union Hosp, Dept Colorectal Surg, Fuzhou, Peoples R China Fujian Medical University; Fujian Medical University Liu, X; Guan, GX (通讯作者)，Fujian Med Univ, Affiliated Hosp 1, Dept Colorectal Surg, Fuzhou, Peoples R China.; Guan, GX (通讯作者)，Fujian Med Univ, Union Hosp, Dept Colorectal Surg, Fuzhou, Peoples R China. xhyyggx@fjmu.edu.cn; fjmufylx@163.com   National Foundation of China [82172800]; Science Foundation of the Fujian Province [2019J01161]; Special Financial Foundation of Fujian Provincial [2015-1297, 2020B019]; Joint Funds for the innovation of science and Technology, Fujian province [2020Y9125]; Funds for the innovation of medical, Fujian province [2021CXB009]; First Affiliated Hospital of Fujian Medical University [YJRC3600] National Foundation of China; Science Foundation of the Fujian Province(Natural Science Foundation of Fujian Province); Special Financial Foundation of Fujian Provincial; Joint Funds for the innovation of science and Technology, Fujian province; Funds for the innovation of medical, Fujian province; First Affiliated Hospital of Fujian Medical University This study was supported by the National Foundation of China (grant no. 82172800), Science Foundation of the Fujian Province, (grant no. 2019J01161), Special Financial Foundation of Fujian Provincial (grant no. 2015-1297; 2020B019), the Joint Funds for the innovation of science and Technology, Fujian province (grant no. 2020Y9125), the Funds for the innovation of medical, Fujian province (grant no. 2021CXB009), and Talent programs granted from The First Affiliated Hospital of Fujian Medical University (grant no. YJRC3600).  37 0 0 2 2 FRONTIERS MEDIA SA LAUSANNE AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND 2296-875X   FRONT SURG Front. Surg. JAN 6 2023 9        1003854 10.3389/fsurg.2022.1003854 http://dx.doi.org/10.3389/fsurg.2022.1003854   9 Surgery Science Citation Index Expanded (SCI-EXPANDED) Surgery 7Z9ML 36684218 Green Published, gold   2023-03-28 WOS:000915874900001 Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1003854 495 Wang,Rui;Liang,Ze-Yan;Chen,Yan;Chen,Chun-Mei Clinical evaluation of paraspinal mini-tubular technique vs. laminoplasty for spinal intradural extramedullary tumors: Study protocol for a multicenter, randomized controlled trial Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1053885 496 Fang,Meiqin;Chen,Mingduan;Chen,Shuchen;Du,Xiaoqiang Predictive nomogram for postoperative atrial fibrillation in locally advanced esophageal squamous carcinoma cell with neoadjuvant treatment Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1089930 497 Han,Wu;Weng,Kai;Zhang,Peipei;Hong,Zhinuan Predictive value of systemic immune-inflammation index for pathological complete response in patients receiving neoadjuvant immunochemotherapy for locally advanced esophageal cancer Surgery FRONTIERS IN SURGERY 2.568 9 / 10.3389/fsurg.2022.1091601 498 Hong,Zhi-Nuan;Weng,Kai;Chen,Zhen;Peng,Kaiming;Kang,Mingqiang Difference between Lung Age and Real Age as a Novel Predictor of Postoperative Complications, Long-Term Survival for Patients with Esophageal Cancer after Minimally Invasive Esophagectomy FRONTIERS IN SURGERY   English Article      esophagectomy; lung age; pulmonary function test; impaired pulmonary function; esophageal cancer SQUAMOUS-CELL CARCINOMA; PREOPERATIVE RESPIRATORY REHABILITATION; PULMONARY COMPLICATIONS; MORTALITY; RISK; MORBIDITY; SURGERY; COPD Background: This study aimed to investigate whether the difference between lung age  and real age (L-R) could be useful for the prediction of postoperative complications and long-term survival in patients with esophageal cancer followed by minimally invasive esophagectomy (MIE). Methods: This retrospective cohort study included 625 consecutive patients who had undergone MIE. Lung age  was determined by the calculation method proposed by the Japanese Respiratory Society. According to L-R, patients were classified into three groups: group A: L-R ? 0 (n = 104), group B: 15 > L-R > 0 (n = 199), group C: L-R >= 15 (n = 322). Clinicopathological factors, postoperative complications evaluated by comprehensive complications index (CCI), and overall survival were compared between the groups. A CCI value > 30 indicated a severe postoperative complication. Results: Male, smoking status, smoking index, chronic obstructive pulmonary disease, American Society of Anesthesiologists status, lung age, and forced expiratory volume in 1 s were associated with group classification. CCI values, postoperative hospital stays, and hospital costs were significantly different among groups. Multivariate analysis indicated that L-R, coronary heart disease, and 3-field lymphadenectomy were significant factors for predicting CCI value > 30. Regarding the prediction of CCI value > 30, area under the curve value was 0.61(95%: 0.56-0.67), 0.46 (95% CI, 0.40-0.54), and 0.46 (95% CI, 0.40-0.54) for L-R, Fev1, and Fev1%, respectively. Regarding overall survival, there was a significant difference between group A and group B + C (log-rank test: p = 0.03). Conclusions: Esophageal cancer patients with impaired pulmonary function had a higher risk of severe postoperative complications and poorer prognosis than those with normal pulmonary function. The difference between lung age  and real age  seems to be a novel and potential predictor of severe postoperative complications and long-term survival. [Hong, Zhi-Nuan; Weng, Kai; Chen, Zhen; Peng, Kaiming; Kang, Mingqiang] Fujian Med Univ, Union Hosp, Dept Thorac Surg, Fuzhou, Peoples R China; [Hong, Zhi-Nuan; Weng, Kai; Chen, Zhen; Peng, Kaiming; Kang, Mingqiang] Fujian Med Univ, Fujian Prov Univ, Key Lab Cardiothorac Surg, Fuzhou, Peoples R China; [Hong, Zhi-Nuan; Weng, Kai; Chen, Zhen; Peng, Kaiming; Kang, Mingqiang] Fujian Med Univ, Key Lab Minist Educ Gastrointestinal Canc, Fuzhou, Peoples R China; [Hong, Zhi-Nuan; Weng, Kai; Chen, Zhen; Peng, Kaiming; Kang, Mingqiang] Fujian Med Univ, Fujian Key Lab Tumor Microbiol, Fuzhou, Peoples R China Fujian Medical University; Fujian Medical University; Fuzhou University; Fujian Medical University; Fujian Medical University Hong, ZN; Kang, MQ (通讯作者)，Fujian Med Univ, Union Hosp, Dept Thorac Surg, Fuzhou, Peoples R China.; Hong, ZN; Kang, MQ (通讯作者)，Fujian Med Univ, Fujian Prov Univ, Key Lab Cardiothorac Surg, Fuzhou, Peoples R China.; Hong, ZN; Kang, MQ (通讯作者)，Fujian Med Univ, Key Lab Minist Educ Gastrointestinal Canc, Fuzhou, Peoples R China.; Hong, ZN; Kang, MQ (通讯作者)，Fujian Med Univ, Fujian Key Lab Tumor Microbiol, Fuzhou, Peoples R China. kangmingqiang0799@163.com; hongzhinuan@163.com   Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University; National Natural Science Foundation of China [81773129, 82070499]; Natural Science Foundation of Fujian Province of China [2020J011036]; Program for Innovative Research Team in Science and technology in Fujian Province University [2018B053] Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University; National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC)); Natural Science Foundation of Fujian Province of China(Natural Science Foundation of Fujian Province); Program for Innovative Research Team in Science and technology in Fujian Province University(Program for Changjiang Scholars & Innovative Research Team in University (PCSIRT)) This study was sponsored by Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, National Natural Science Foundation of China (grant number: 81773129 and 82070499), Natural Science Foundation of Fujian Province of China (grant number 2020J011036), and Program for Innovative Research Team in Science and technology in Fujian Province University (grant number 2018B053).  30 1 1 2 3 FRONTIERS MEDIA SA LAUSANNE AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND 2296-875X   FRONT SURG Front. 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